Carboxyl-substituted glucocorticoid receptor agonists

The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof: # imgabs0 # wherein R1 is H, halogen, a C1-C3 alkyl group, or a C1-C3 alkoxy group; r2 is H or halogen; and X is O, OCH2 or CH2; wherein the compound of formula I or a pharmaceutically acceptable salt thereof is useful in the treatment of autoimmune and inflammatory diseases, such as atopic dermatitis, rheumatoid arthritis and lupus nephritis. 本发明提供了式I的化合物或其可药用盐：#imgabs0#其中R1是H、卤素、C1-C3烷基或C1-C3烷氧基；R2是H或卤素；且X是是O、OCH2或CH2；其中所述式I的化合物或其可药用盐用于治疗自身免疫性疾病和炎性疾病，例如特应性皮炎、类风湿性关节炎和狼疮肾炎。