CHIMERIC ANTIGEN RECEPTOR (CAR)-T CELLS EXPRESSING CXCL12 RECEPTOR

The present invention provides: a cell which co-expresses a chimeric antigen receptor (CAR) protein and a CXCL12 receptor protein on a cell membrane; a drug and a pharmaceutical composition which contain the cell and have antitumor activity; as a therapeutic method for radically treating hematologic...

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Bibliographische Detailangaben
Hauptverfasser:	SCHULTZ, LOREN, D, SAITO YORIKO, ISHIKAWA FUMIHIKO, ITO ASATO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides: a cell which co-expresses a chimeric antigen receptor (CAR) protein and a CXCL12 receptor protein on a cell membrane; a drug and a pharmaceutical composition which contain the cell and have antitumor activity; as a therapeutic method for radically treating hematological neoplastic diseases with poor prognosis; and a method for treating hematological neoplastic diseases with poor prognosis. 本发明提供细胞、含有该细胞且具抗肿瘤活性的药剂和药物组合物作为用于根治预后不良的血液肿瘤性疾病的治疗方法，所述细胞在细胞膜上共表达嵌合抗原受体(CAR)蛋白和CXCL12受体蛋白。