Biomarker for atopic dermatitis and application thereof
The invention discloses a biomarker for atopic dermatitis and application of the biomarker. The inventor of the invention adopts liquid chromatography-mass spectrometry and data independent acquisition technology detection to find that the expression of aminolevulinic acid dehydratase (ALAD) in the...
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| creator | LIU JUNFENG ZHANG KAI MO XIUMEI YE SIQI YAN FENGGEN YU XIAOBO CHEN DACAN WANG SAIYA |
| description | The invention discloses a biomarker for atopic dermatitis and application of the biomarker. The inventor of the invention adopts liquid chromatography-mass spectrometry and data independent acquisition technology detection to find that the expression of aminolevulinic acid dehydratase (ALAD) in the blood of an atopic dermatitis patient is obviously reduced, and the ALAD can be well used as a marker for atopic dermatitis diagnosis and reaction severity, can provide objective laboratory indexes for disease diagnosis, and has a good application prospect. Precise treatment can be realized, and the method has important significance for improving the clinical curative effect.
本发明公开了特应性皮炎的生物标志物及其应用。本发明的发明人采用液质联用、数据非依赖性采集技术检测，发现特应性皮炎患者血液中氨基乙酰丙酸脱水酶(ALAD)表达明显下降，其能够很好作为特应性皮炎诊断和反应严重程度的标志物，可以为疾病的诊断提供客观的实验室指标，有助于实现精准治疗，对于提高临床疗效有重要意义。 |
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本发明公开了特应性皮炎的生物标志物及其应用。本发明的发明人采用液质联用、数据非依赖性采集技术检测，发现特应性皮炎患者血液中氨基乙酰丙酸脱水酶(ALAD)表达明显下降，其能够很好作为特应性皮炎诊断和反应严重程度的标志物，可以为疾病的诊断提供客观的实验室指标，有助于实现精准治疗，对于提高临床疗效有重要意义。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231013&DB=EPODOC&CC=CN&NR=116875675A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20231013&DB=EPODOC&CC=CN&NR=116875675A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIU JUNFENG</creatorcontrib><creatorcontrib>ZHANG KAI</creatorcontrib><creatorcontrib>MO XIUMEI</creatorcontrib><creatorcontrib>YE SIQI</creatorcontrib><creatorcontrib>YAN FENGGEN</creatorcontrib><creatorcontrib>YU XIAOBO</creatorcontrib><creatorcontrib>CHEN DACAN</creatorcontrib><creatorcontrib>WANG SAIYA</creatorcontrib><title>Biomarker for atopic dermatitis and application thereof</title><description>The invention discloses a biomarker for atopic dermatitis and application of the biomarker. The inventor of the invention adopts liquid chromatography-mass spectrometry and data independent acquisition technology detection to find that the expression of aminolevulinic acid dehydratase (ALAD) in the blood of an atopic dermatitis patient is obviously reduced, and the ALAD can be well used as a marker for atopic dermatitis diagnosis and reaction severity, can provide objective laboratory indexes for disease diagnosis, and has a good application prospect. Precise treatment can be realized, and the method has important significance for improving the clinical curative effect.
本发明公开了特应性皮炎的生物标志物及其应用。本发明的发明人采用液质联用、数据非依赖性采集技术检测，发现特应性皮炎患者血液中氨基乙酰丙酸脱水酶(ALAD)表达明显下降，其能够很好作为特应性皮炎诊断和反应严重程度的标志物，可以为疾病的诊断提供客观的实验室指标，有助于实现精准治疗，对于提高临床疗效有重要意义。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB3yszPTSzKTi1SSMsvUkgsyS_ITFZISS3KTSzJLMksVkjMS1FILCjIyUwGCuTnKZRkpBal5qfxMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLE5NS81JJ4Zz9DQzMLc1Mzc1NHY2LUAADu_y5H</recordid><startdate>20231013</startdate><enddate>20231013</enddate><creator>LIU JUNFENG</creator><creator>ZHANG KAI</creator><creator>MO XIUMEI</creator><creator>YE SIQI</creator><creator>YAN FENGGEN</creator><creator>YU XIAOBO</creator><creator>CHEN DACAN</creator><creator>WANG SAIYA</creator><scope>EVB</scope></search><sort><creationdate>20231013</creationdate><title>Biomarker for atopic dermatitis and application thereof</title><author>LIU JUNFENG ; ZHANG KAI ; MO XIUMEI ; YE SIQI ; YAN FENGGEN ; YU XIAOBO ; CHEN DACAN ; WANG SAIYA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116875675A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LIU JUNFENG</creatorcontrib><creatorcontrib>ZHANG KAI</creatorcontrib><creatorcontrib>MO XIUMEI</creatorcontrib><creatorcontrib>YE SIQI</creatorcontrib><creatorcontrib>YAN FENGGEN</creatorcontrib><creatorcontrib>YU XIAOBO</creatorcontrib><creatorcontrib>CHEN DACAN</creatorcontrib><creatorcontrib>WANG SAIYA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIU JUNFENG</au><au>ZHANG KAI</au><au>MO XIUMEI</au><au>YE SIQI</au><au>YAN FENGGEN</au><au>YU XIAOBO</au><au>CHEN DACAN</au><au>WANG SAIYA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Biomarker for atopic dermatitis and application thereof</title><date>2023-10-13</date><risdate>2023</risdate><abstract>The invention discloses a biomarker for atopic dermatitis and application of the biomarker. The inventor of the invention adopts liquid chromatography-mass spectrometry and data independent acquisition technology detection to find that the expression of aminolevulinic acid dehydratase (ALAD) in the blood of an atopic dermatitis patient is obviously reduced, and the ALAD can be well used as a marker for atopic dermatitis diagnosis and reaction severity, can provide objective laboratory indexes for disease diagnosis, and has a good application prospect. Precise treatment can be realized, and the method has important significance for improving the clinical curative effect.
本发明公开了特应性皮炎的生物标志物及其应用。本发明的发明人采用液质联用、数据非依赖性采集技术检测，发现特应性皮炎患者血液中氨基乙酰丙酸脱水酶(ALAD)表达明显下降，其能够很好作为特应性皮炎诊断和反应严重程度的标志物，可以为疾病的诊断提供客观的实验室指标，有助于实现精准治疗，对于提高临床疗效有重要意义。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE |
| title | Biomarker for atopic dermatitis and application thereof |
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