Reduced glutathione responsive cationic polymer as well as preparation method and application thereof

The invention discloses a reduced glutathione responsive cationic polymer as well as a preparation method and application thereof. The cationic polymer has a structure as shown in the following formula: # imgabs0 #, in the formula, m is 5-500, and n is 5-500. Compared with commercialized PEI25kDa, t...

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Bibliographische Detailangaben
Hauptverfasser:	QIAN LINSHENG, ZHAO DELIN, CUI XIANGLIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS THEIR PREPARATION OR CHEMICAL WORKING-UP VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a reduced glutathione responsive cationic polymer as well as a preparation method and application thereof. The cationic polymer has a structure as shown in the following formula: # imgabs0 #, in the formula, m is 5-500, and n is 5-500. Compared with commercialized PEI25kDa, the reduced glutathione responsive cationic polymer disclosed by the invention is lower in cytotoxicity and higher in uptake efficiency, and has potential practical value of gene therapy. 本发明公开了一种还原型谷胱甘肽响应的阳离子聚合物及其制法与应用。所述阳离子聚合物具有如下式所示的结构：#imgabs0#其中，m为5～500，n为5～500。本发明中的还原型谷胱甘肽响应的阳离子聚合物较商业化PEI25kDa细胞毒性更小、摄取效率更高，具有基因治疗的潜在实用价值。