Synthesis and application of small molecule compound with 2-pyridine substituted formamide structure

The invention relates to a small-molecule inhibitor of ASK1 kinase, in particular to synthesis and application of a small-molecule compound with a 2-pyridine substituted formamide structure, a pharmaceutical composition of the small-molecule compound and application of the small-molecule compound in preparation of the ASK1 small-molecule inhibitor, or prevention and/or treatment of ASK1-related diseases, such as ASK1-related diseases, ASK1-related diseases and ASK1-related diseases. The pharmaceutical composition can be applied to medicines for treating liver diseases, lung diseases, tumors, cardiovascular diseases, kidney diseases and metabolic diseases, especially liver diseases, lung diseases, tumors, cardiovascular diseases, kidney diseases and metabolic diseases. 本发明涉及一类ASK1激酶的小分子抑制剂，具体涉及一种具有2-吡啶取代甲酰胺结构的小分子化合物的合成和应用，及其药物组合物和在制备ASK1小分子抑制剂，或预防和/或治疗与ASK1相关疾病，尤其是肝脏疾病、肺部疾病、肿瘤、心血管疾病、肾脏疾病和代谢性疾病的药物中的用途。