Monoclonal antibody anti alpha; V-integrin and it use to inhibit alpha; beta; 6-integrain attachment to fibronectine

本发明涉及一种新的单克隆抗体和产生该抗体的杂交瘤细胞系。该单克隆抗体的一个优选的实施方案命名为14D9.F8，具有以下特性：仅与人αv整联蛋白的αv链反应，以及选择性抑制与αvβ6整联蛋白承载细胞的整联蛋白底物纤连蛋白的附着。 The invention relates to a novel monoclonal antibody and a hybridoma cell line producing said antibody. The monoclonal antibody, a preferred embodiment of which is named 14D9.F8, has the...

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Bibliographische Detailangaben
Hauptverfasser:	B. DIEFENBACH, F. MITJANS, S. GOODMAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	本发明涉及一种新的单克隆抗体和产生该抗体的杂交瘤细胞系。该单克隆抗体的一个优选的实施方案命名为14D9.F8，具有以下特性：仅与人αv整联蛋白的αv链反应，以及选择性抑制与αvβ6整联蛋白承载细胞的整联蛋白底物纤连蛋白的附着。 The invention relates to a novel monoclonal antibody and a hybridoma cell line producing said antibody. The monoclonal antibody, a preferred embodiment of which is named 14D9.F8, has the following properties: reacting only with the alpha v-chain of human alpha v-integrins, and inhibiting selectively the attachment to the integrin substrate fibronectin of the alpha v beta 6-integrin bearing cell.