Aryl alkanoylpyridazines compounds

本发明涉及式I的芳基链烷酰基哒嗪衍生物及其生理可接受的盐和溶剂化物，其中，R#+[1]、R#+[2]、Q和B具有权利要求1中所述的含义。所述化合物可以抑制磷酸二酯酶-IV并可用于治疗过敏性疾病、哮喘、慢性支气管炎、特应性皮炎、牛皮癣和其它皮肤疾病、炎性疾病、自身免疫疾病例如类风湿性关节炎、多发性硬化、节段性回肠炎、糖尿病或溃疡性结肠炎、骨质疏松、移植物排斥反应、恶病质、肿瘤生长或肿瘤转移、脓毒症、记忆力障碍、动脉粥样硬化和AIDS。∴ Arylalkanoylpyridazine derivatives of the formula Iand their physiologically acceptable salts and solvates,in whichR1, R2, Q and B have the meanings indicated in Claim 1, show an inhibition of phosphodiesterase IV and can be employed for the treatment of asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, autoimmune disorders, such as, for example, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumor growth or tumor metastases, sepsis, memory disorders, atherosclerosis and AIDS.