Preparation method of antibacterial collagen sponge

The invention discloses a preparation method of a bacteriostatic collagen sponge, which specifically comprises the following steps: degreasing bovine achilles tendon, dissolving with acid, performing enzymolysis, salting out, swelling and dialyzing, crosslinking and freeze-drying to obtain the collagen sponge with biological activity. The collagen sponge is immersed in the chelerythrine alkali solution; taking out the collagen sponge from the chelerythrine solution, and soaking the collagen sponge in drinking water; after soaking is finished, taking out the collagen sponge, and then removing residues of the organic solvent in the collagen sponge; and putting the collagen sponge from which the organic solvent residues are removed into a freeze dryer for drying and freeze-drying to obtain a finished product. According to the invention, chelerythrine achieves the inhibition effect on bacteria by reducing the adhesion capacity between bacteria, breaking a bacterial chain and reducing the surface hydrophobicity, a