Application of 3, 19-site amino-containing andrographolide derivative in preparation of anti-inflammatory drugs

The invention belongs to the field of pharmaceutical synthesis, and particularly relates to application of 3, 19-site amino-containing andrographolide derivatives in preparation of anti-inflammatory drugs. The general formula (X) is shown as the following: # imgabs0 #, in the general formula (X), R is selected from substituted or unsubstituted 5-6-membered aromatic heterocyclic groups or phenyl groups, and the substituent groups are selected from one or more of halogen, trifluoromethyl, methoxyl and methyl. The andrographolide derivative has a good anti-inflammatory activity prospect. 本发明属于药物学合成领域，具体为3,19位含胺基的穿心莲内酯衍生物在制备抗炎药物中的应用。所述通式(X)如以下所示：#imgabs0#所述通式(X)中，R选自取代或未取代的5-6元芳香杂环基或苯基，所述取代基选自卤素、三氟甲基、甲氧基、甲基、中的一个或多个。该穿心莲内酯衍生物具有良好的抗炎活性前景。