Tilmicosin injection and preparation method thereof

The invention provides a tilmicosin injection. The tilmicosin injection comprises tilmicosin and a pharmaceutically acceptable organic solvent, wherein the pharmaceutically acceptable organic solvent is selected from one or more of alpha-pyrrolidone, ethanol, propylene glycol, dimethylformamide and...

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Hauptverfasser: PENG GUOPING, ZHANG LIANG, YAN JIAO, ZOU, YONGZHONG, PI YANHUA, MAO YINHUA, MIAO CHAO, ZHU DECHANG
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creator PENG GUOPING
ZHANG LIANG
YAN JIAO
ZOU, YONGZHONG
PI YANHUA
MAO YINHUA
MIAO CHAO
ZHU DECHANG
description The invention provides a tilmicosin injection. The tilmicosin injection comprises tilmicosin and a pharmaceutically acceptable organic solvent, wherein the pharmaceutically acceptable organic solvent is selected from one or more of alpha-pyrrolidone, ethanol, propylene glycol, dimethylformamide and benzyl alcohol. In addition, the invention also provides a preparation method. According to the tilmicosin injection, tilmicosin with the content larger than 98% can be adopted as a raw material for production, compared with tilmicosin phosphate (with the content smaller than 77%), the use amount of the raw material in liquid medicine is greatly reduced, and the viscosity of the liquid medicine is greatly reduced to a certain degree. 本发明提供一种替米考星注射液,包括替米考星、药物上可接受的有机溶媒;其中所述药物上可接受的有机溶媒选自α-吡咯烷酮、乙醇、丙二醇、二甲基甲酰胺、苯甲醇的一种或几种。另外,还提供其制备方法。本发明替米考星注射液,可以采用含量大于98%替米考星作为原料进行生产,相比使用磷酸替米考星(含量低于77%)大大减少了药液中原料的使用量,在一定程度上大大减少药液的黏稠度。
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The tilmicosin injection comprises tilmicosin and a pharmaceutically acceptable organic solvent, wherein the pharmaceutically acceptable organic solvent is selected from one or more of alpha-pyrrolidone, ethanol, propylene glycol, dimethylformamide and benzyl alcohol. In addition, the invention also provides a preparation method. According to the tilmicosin injection, tilmicosin with the content larger than 98% can be adopted as a raw material for production, compared with tilmicosin phosphate (with the content smaller than 77%), the use amount of the raw material in liquid medicine is greatly reduced, and the viscosity of the liquid medicine is greatly reduced to a certain degree. 本发明提供一种替米考星注射液,包括替米考星、药物上可接受的有机溶媒;其中所述药物上可接受的有机溶媒选自α-吡咯烷酮、乙醇、丙二醇、二甲基甲酰胺、苯甲醇的一种或几种。另外,还提供其制备方法。本发明替米考星注射液,可以采用含量大于98%替米考星作为原料进行生产,相比使用磷酸替米考星(含量低于77%)大大减少了药液中原料的使用量,在一定程度上大大减少药液的黏稠度。</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20231013&amp;DB=EPODOC&amp;CC=CN&amp;NR=116869929A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20231013&amp;DB=EPODOC&amp;CC=CN&amp;NR=116869929A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PENG GUOPING</creatorcontrib><creatorcontrib>ZHANG LIANG</creatorcontrib><creatorcontrib>YAN JIAO</creatorcontrib><creatorcontrib>ZOU, YONGZHONG</creatorcontrib><creatorcontrib>PI YANHUA</creatorcontrib><creatorcontrib>MAO YINHUA</creatorcontrib><creatorcontrib>MIAO CHAO</creatorcontrib><creatorcontrib>ZHU DECHANG</creatorcontrib><title>Tilmicosin injection and preparation method thereof</title><description>The invention provides a tilmicosin injection. 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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Tilmicosin injection and preparation method thereof
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