Tilmicosin injection and preparation method thereof

The invention provides a tilmicosin injection. The tilmicosin injection comprises tilmicosin and a pharmaceutically acceptable organic solvent, wherein the pharmaceutically acceptable organic solvent is selected from one or more of alpha-pyrrolidone, ethanol, propylene glycol, dimethylformamide and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PENG GUOPING, ZHANG LIANG, YAN JIAO, ZOU, YONGZHONG, PI YANHUA, MAO YINHUA, MIAO CHAO, ZHU DECHANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a tilmicosin injection. The tilmicosin injection comprises tilmicosin and a pharmaceutically acceptable organic solvent, wherein the pharmaceutically acceptable organic solvent is selected from one or more of alpha-pyrrolidone, ethanol, propylene glycol, dimethylformamide and benzyl alcohol. In addition, the invention also provides a preparation method. According to the tilmicosin injection, tilmicosin with the content larger than 98% can be adopted as a raw material for production, compared with tilmicosin phosphate (with the content smaller than 77%), the use amount of the raw material in liquid medicine is greatly reduced, and the viscosity of the liquid medicine is greatly reduced to a certain degree. 本发明提供一种替米考星注射液,包括替米考星、药物上可接受的有机溶媒;其中所述药物上可接受的有机溶媒选自α-吡咯烷酮、乙醇、丙二醇、二甲基甲酰胺、苯甲醇的一种或几种。另外,还提供其制备方法。本发明替米考星注射液,可以采用含量大于98%替米考星作为原料进行生产,相比使用磷酸替米考星(含量低于77%)大大减少了药液中原料的使用量,在一定程度上大大减少药液的黏稠度。