4-aminoquinazoline compounds

Provided is a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer. The inventors have studied a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer, and found that a 4-aminoquinazoline compound has...

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Hauptverfasser: KURIWAKI IKUMI, HAMAGUCHI HISAO, OKUMURA, MITSUAKI, NAGASHIMA TAKEYUKI, KAWAGUCHI KENICHI, KURAMOTO KAZUYUKI, SATO RYO, SEKI YOHEI, MORIKAWA TAKAHIRO, ISHIOKA HIROKI, FUKUDOME HIROKI, IMADA SUNAO, IMAIZUMI TOMOYOSHI, KAWAMINAMI EIJI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Provided is a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer. The inventors have studied a compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer, and found that a 4-aminoquinazoline compound has an excellent G12D mutation KRAS inhibitory activity and can be used as a therapeutic agent for pancreatic cancer, thereby completing the present invention. The 4-aminoquinazoline compound or a salt thereof according to the present invention can be used as a therapeutic agent for pancreatic cancer. # imgabs0 # 本发明提供作为胰腺癌治疗用药物组合物的有效成分有用的化合物。本发明人对于作为胰腺癌治疗用药物组合物的有效成分有用的化合物进行了研究,发现4-氨基喹唑啉化合物具有优良的G12D突变KRAS抑制活性,可作为胰腺癌的治疗剂使用,从而完成了本发明。本发明的4-氨基喹唑啉化合物或其盐可作为胰腺癌的治疗剂使用。#imgabs0#