Hydrogel loaded with nisin nanoparticles and preparation method thereof

The invention provides a preparation method of hydrogel loaded with nisin nanoparticles, which comprises the following steps: S1, mixing a chitosan solution with a beta-sodium glycerophosphate solution, stirring in an ice bath to obtain a mixed solution, and performing water bath treatment on the mixed solution to obtain a hydrogel mixed solution; s2, selecting nisin, purifying, adding water to obtain a nisin aqueous solution, mixing the nisin aqueous solution with the gamma-polyglutamic acid aqueous solution, stirring to obtain a mixed solution, adding the mixed solution into the chitosan acetic acid solution, and stirring again to obtain a nanoparticle solution; s3, homogenizing the nano particle solution, and filtering to remove impurities to obtain a pure nano particle solution; and S4, adding the pure nanoparticle solution into the hydrogel mixed solution, stirring, and heating in a water bath to gel the solution, so as to obtain the hydrogel loaded with nisin nanoparticles. The hydrogel prepared by the