Conjugated oligonucleotide compounds, methods of making and uses thereof

The present invention provides novel conjugated oligonucleotide compounds suitable for therapeutic use. In addition, the invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and disorders. 本发明提供适用于治疗用途的新型缀合寡核苷酸化合物。此外，本发明提供制备这些化合物的方法，以及使用此类化合物用于治疗各种疾病和病症的方法。