Oxadiazole derivative as well as preparation method and application thereof

The invention provides an oxadiazole derivative as well as a preparation method and application thereof, the structure of the oxadiazole derivative is as shown in formula I, # imgabs0. The oxadiazole derivative provided by the invention has a very good agonistic effect on S1P1, and can be used for preparing a compound with a good agonistic effect on S1P1; the compound can be used for treating or preventing autoimmune diseases such as multiple sclerosis, inflammatory enteritis, rheumatoid arthritis, atopic dermatitis, transplanted versus host disease or psoriasis. 本发明提供一种噁二唑衍生物及其制备方法和用途，其中，噁二唑衍生物的结构如式一所示，#imgabs0#本发明提供的噁二唑衍生物对S1P1具有非常好的激动作用，可以作为治疗或预防例如多发性硬化症、炎症性肠炎、类风湿性关节炎、特应性皮炎、移植性抗宿主病或银屑病等自身免疫性疾病。