Levothyroxine sodium sustained-release microsphere freeze-dried preparation for injection and preparation method thereof

The invention provides a levothyroxine sodium sustained-release microsphere freeze-dried preparation for injection, which is prepared from the following components in parts by weight: 10 to 20 parts of levothyroxine sodium, 30 to 60 parts of polylactic acid-glycolic acid copolymer, 10 to 20 parts of polyvinyl alcohol and 2 to 4 parts of sodium chloride. According to the levothyroxine sodium sustained-release microsphere freeze-dried preparation for injection and the preparation method, 1, through sustained release, daily medicine taking can be avoided, and a patient is prevented from forgetting to take medicine; 2, the preparation is good in appearance and short in redissolution time; 本发明提供了一种注射用左甲状腺素钠缓释微球冻干制剂，包括：左甲状腺素钠10-20重量份、聚乳酸-羟基乙酸共聚物30-60重量份，聚乙烯醇10-20重量份，氯化钠2-4重量份，本发明的有益效果在于，本发明的提供了一种注射用左甲状腺素钠缓释微球冻干制剂及制备方法，1.通过缓释，可以避免每日服药，避免病人忘记服药；2.本发明制剂外观良好，复溶时间短。