Polynucleotides encoding interleukin-12 (IL-12) and compositions and methods related thereto

Provided herein are nucleic acid molecules encoding interleukin-12 (IL-12), or polypeptides comprising IL-12 or a functional fragment of IL-12. Also provided herein are compositions, including lipid nanoparticles (LNPs), comprising the nucleic acid molecules, and related therapeutic methods and uses for the control or treatment of human cancer. 本文提供了编码白细胞介素-12(IL-12)的核酸分子，或包含IL-12或IL-12的功能片段的多肽。本文还提供了包含所述核酸分子的组合物，包括脂质纳米颗粒(LNP)，以及用于控制或治疗人类癌症的相关治疗方法和用途。