Improved process for preparing microcrystalline cellulose

Ground dried microcrystalline cellulose (MCC) is obtained in a process comprising the steps of: a) providing MCC having a moisture content of from 20% to 75% based on the total weight of moist MCC; and b) grinding and drying the moist MCC in a single device capable of performing grinding and drying...

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Bibliographische Detailangaben
Hauptverfasser: WOZNIUK, OLIVER, SCHRECK MICHAEL, SPREHE MATTHEW R, GUO JIANGANG, JUNGE STEPHAN, KELLING RALF
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Ground dried microcrystalline cellulose (MCC) is obtained in a process comprising the steps of: a) providing MCC having a moisture content of from 20% to 75% based on the total weight of moist MCC; and b) grinding and drying the moist MCC in a single device capable of performing grinding and drying in combination. The method can provide ground dried microcrystalline cellulose having a particle size distribution (LEFI, DIFI, and EQPC) and moisture content similar to corresponding spray dried microcrystalline cellulose. The method can provide ground dried microcrystalline cellulose having a higher tap/untap bulk density and/or a lower Karl index compared to corresponding spray dried microcrystalline cellulose while maintaining similar moisture content. 研磨干燥的微晶纤维素(MCC)在包括以下步骤的方法中获得:a)提供具有基于潮湿MCC的总重量20%至75%的水分含量的MCC;以及b)在能够组合地进行研磨和干燥的单个装置中研磨干燥该潮湿MCC。该方法可以提供研磨干燥的微晶纤维素,其具有与对应的喷雾干燥的微晶纤维素类似的粒度分布(LEFI、DIFI和EQPC)和水分含量。该方法可以提供研磨干燥的微晶纤维素,与对应的喷雾干燥的微晶纤维素相比,其具有更高的振实/未振实堆积密度和/或更低的卡尔指数,同时保持类似的水分含量。