Sample size expansion method and device, equipment and storage medium

The embodiment of the invention discloses a sample size expansion method and device, equipment and a storage medium. The method comprises the following steps: acquiring a digital pathological image comprising a first image area marked with a positive sample label, a second image area marked with a negative sample label and a third image area not marked with a label; performing image segmentation on the third image area to obtain a plurality of sub-images of the third image area; performing similarity clustering processing on image features by using the first image region, the second image region and each subimage, and determining a similarity degree pair of each subimage; and determining target sample labels corresponding to the sub-images according to the similarity degree pairs of the sub-images and a preset similarity coordinate system. According to the method, the sample size expansion from small data annotation to big data annotation of the digital pathological image is realized, and compared with manual