Anti-candida Ssa1 monoclonal antibody and application thereof
The invention discloses an anti-candida Ssa1 monoclonal antibody and an application of the anti-candida Ssa1 monoclonal antibody. The monoclonal antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises heavy chain complemen...
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| creator | QIU XIRAN AN MAOMAO SHEN HUI |
| description | The invention discloses an anti-candida Ssa1 monoclonal antibody and an application of the anti-candida Ssa1 monoclonal antibody. The monoclonal antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises heavy chain complementarity determining regions HCDR1-HCDR3 as shown in SEQ ID NO: 1-3; the light chain variable region comprises light chain complementary determining regions (LCDR1-LCDR3) as shown in SEQ ID NO: 4-6. The monoclonal antibody provided by the invention has in-vitro affinity to Candida albicans Ssa1 protein, has pharmacodynamic activity of resisting Candida albicans infection in an animal body, has a protection effect on mouse infection caused by Candida albicans, and has a prospect of being prepared into a Candida albicans infection resisting medicine.
本发明公开了一种抗念珠菌Ssa1单克隆抗体及其应用。所述单克隆抗体包括重链可变区和轻链可变区，所述重链可变区包含SEQ ID NO:1～3所示的重链互补决定区HCDR1～HCDR3；所述轻链可变区包含SEQ ID NO:4～6所示的轻链互补决定区LCDR1～LCDR3。本发明提供的单克隆抗体对白念珠菌Ssa1蛋白具有体外亲和力，并且在动物体 |
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本发明公开了一种抗念珠菌Ssa1单克隆抗体及其应用。所述单克隆抗体包括重链可变区和轻链可变区，所述重链可变区包含SEQ ID NO:1～3所示的重链互补决定区HCDR1～HCDR3；所述轻链可变区包含SEQ ID NO:4～6所示的轻链互补决定区LCDR1～LCDR3。本发明提供的单克隆抗体对白念珠菌Ssa1蛋白具有体外亲和力，并且在动物体</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2023</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230929&DB=EPODOC&CC=CN&NR=116813763A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20230929&DB=EPODOC&CC=CN&NR=116813763A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>QIU XIRAN</creatorcontrib><creatorcontrib>AN MAOMAO</creatorcontrib><creatorcontrib>SHEN HUI</creatorcontrib><title>Anti-candida Ssa1 monoclonal antibody and application thereof</title><description>The invention discloses an anti-candida Ssa1 monoclonal antibody and an application of the anti-candida Ssa1 monoclonal antibody. The monoclonal antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises heavy chain complementarity determining regions HCDR1-HCDR3 as shown in SEQ ID NO: 1-3; the light chain variable region comprises light chain complementary determining regions (LCDR1-LCDR3) as shown in SEQ ID NO: 4-6. The monoclonal antibody provided by the invention has in-vitro affinity to Candida albicans Ssa1 protein, has pharmacodynamic activity of resisting Candida albicans infection in an animal body, has a protection effect on mouse infection caused by Candida albicans, and has a prospect of being prepared into a Candida albicans infection resisting medicine.
本发明公开了一种抗念珠菌Ssa1单克隆抗体及其应用。所述单克隆抗体包括重链可变区和轻链可变区，所述重链可变区包含SEQ ID NO:1～3所示的重链互补决定区HCDR1～HCDR3；所述轻链可变区包含SEQ ID NO:4～6所示的轻链互补决定区LCDR1～LCDR3。本发明提供的单克隆抗体对白念珠菌Ssa1蛋白具有体外亲和力，并且在动物体</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2023</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB1zCvJ1E1OzEvJTElUCC5ONFTIzc_LT87Jz0vMUUgESiblp1QCGSkKiQUFOZnJiSWZ-XkKJRmpRan5aTwMrGmJOcWpvFCam0HRzTXE2UM3tSA_PrW4IDE5NS-1JN7Zz9DQzMLQ2NzM2NGYGDUA-9EwAQ</recordid><startdate>20230929</startdate><enddate>20230929</enddate><creator>QIU XIRAN</creator><creator>AN MAOMAO</creator><creator>SHEN HUI</creator><scope>EVB</scope></search><sort><creationdate>20230929</creationdate><title>Anti-candida Ssa1 monoclonal antibody and application thereof</title><author>QIU XIRAN ; AN MAOMAO ; SHEN HUI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN116813763A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2023</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>QIU XIRAN</creatorcontrib><creatorcontrib>AN MAOMAO</creatorcontrib><creatorcontrib>SHEN HUI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>QIU XIRAN</au><au>AN MAOMAO</au><au>SHEN HUI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Anti-candida Ssa1 monoclonal antibody and application thereof</title><date>2023-09-29</date><risdate>2023</risdate><abstract>The invention discloses an anti-candida Ssa1 monoclonal antibody and an application of the anti-candida Ssa1 monoclonal antibody. The monoclonal antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises heavy chain complementarity determining regions HCDR1-HCDR3 as shown in SEQ ID NO: 1-3; the light chain variable region comprises light chain complementary determining regions (LCDR1-LCDR3) as shown in SEQ ID NO: 4-6. The monoclonal antibody provided by the invention has in-vitro affinity to Candida albicans Ssa1 protein, has pharmacodynamic activity of resisting Candida albicans infection in an animal body, has a protection effect on mouse infection caused by Candida albicans, and has a prospect of being prepared into a Candida albicans infection resisting medicine.
本发明公开了一种抗念珠菌Ssa1单克隆抗体及其应用。所述单克隆抗体包括重链可变区和轻链可变区，所述重链可变区包含SEQ ID NO:1～3所示的重链互补决定区HCDR1～HCDR3；所述轻链可变区包含SEQ ID NO:4～6所示的轻链互补决定区LCDR1～LCDR3。本发明提供的单克隆抗体对白念珠菌Ssa1蛋白具有体外亲和力，并且在动物体</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Anti-candida Ssa1 monoclonal antibody and application thereof |
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