Anti-candida Ssa1 monoclonal antibody and application thereof

The invention discloses an anti-candida Ssa1 monoclonal antibody and an application of the anti-candida Ssa1 monoclonal antibody. The monoclonal antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises heavy chain complementarity determining regions HCDR1-HCDR3 as shown in SEQ ID NO: 1-3; the light chain variable region comprises light chain complementary determining regions (LCDR1-LCDR3) as shown in SEQ ID NO: 4-6. The monoclonal antibody provided by the invention has in-vitro affinity to Candida albicans Ssa1 protein, has pharmacodynamic activity of resisting Candida albicans infection in an animal body, has a protection effect on mouse infection caused by Candida albicans, and has a prospect of being prepared into a Candida albicans infection resisting medicine. 本发明公开了一种抗念珠菌Ssa1单克隆抗体及其应用。所述单克隆抗体包括重链可变区和轻链可变区，所述重链可变区包含SEQ ID NO:1～3所示的重链互补决定区HCDR1～HCDR3；所述轻链可变区包含SEQ ID NO:4～6所示的轻链互补决定区LCDR1～LCDR3。本发明提供的单克隆抗体对白念珠菌Ssa1蛋白具有体外亲和力，并且在动物体