Preparation method and application of intragastric volume-occupying hydrogel particles for obesity intervention

The invention discloses a preparation method and application of intragastric volume-occupying hydrogel particles for obesity intervention, and belongs to the technical field of hydrogel, the preparation method comprises the following steps: (1) dissolving water-soluble polysaccharide macromolecules to obtain a polysaccharide aqueous solution; (2) a cross-linking agent solution is added into the polysaccharide aqueous solution, high-pressure homogenization is carried out, a composite solution is obtained, the adding speed of the cross-linking agent solution is 1-3 ml/min, and the pressure of high-pressure homogenization is 10000-1300 psi; and (3) drying and crushing the composite solution to obtain the intragastric volume hydrogel particles. The super-hydrophilic porous hydrogel particles are prepared by controlling the adding speed of the cross-linking agent solution and the pressure of high-pressure homogenization. Experiments prove that the intragastric volume hydrogel particles have high water absorption s