IL-2 muteins for treatment of autoimmune and inflammatory diseases

IL-2 muteins for treatment of autoimmune and inflammatory diseases

Provided herein are IL-2 muteins that bind to the IL-2 receptor alpha subunit but do not have measurable binding to the IL-2 receptor beta subunit. Compositions, kits, methods and uses relating to these IL-2 muteins are also provided. 本文提供了IL-2突变蛋白，其结合IL-2受体α亚基但与IL-2受体β亚基不具有可测量的结合。还提供了涉及这些IL-2突变蛋白的组...

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Bibliographische Detailangaben
Hauptverfasser: BEAUMONT MATTHEW, CHENG, ALAN, C, MURRAY ROBERT, SRIRAMAN VIDYA, AZZADI GRAZIANO, BANSAL LALIT, GEORGIEV PAVEL, ALVES SCOTT EDWARD, HALL BENJAMIN E, JUAN VERONICA M, ZHANG-HOVEL, JULIE
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:Provided herein are IL-2 muteins that bind to the IL-2 receptor alpha subunit but do not have measurable binding to the IL-2 receptor beta subunit. Compositions, kits, methods and uses relating to these IL-2 muteins are also provided. 本文提供了IL-2突变蛋白，其结合IL-2受体α亚基但与IL-2受体β亚基不具有可测量的结合。还提供了涉及这些IL-2突变蛋白的组合物、试剂盒、方法和用途。