VIRAL VECTORS AND NUCLEIC ACIDS FOR TREATMENT OF ILD, PF-ILD AND IPF

A viral vector comprising: a capsid and a packaged nucleic acid wherein the nucleic acid enhances miRNA down-regulated in a bleomycin-induced pulmonary fibrosis model or in an AAV-TGF [beta] 1-induced pulmonary fibrosis model, or wherein the nucleic acid inhibits miRNA up-regulated in a bleomycin-in...

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Bibliographische Detailangaben
Hauptverfasser:	IKENSTEIN LARS, CREUTZ SERGE, KLEY SASKIA, KESTLE MARTIN, STROEBER BERND, RAMLA THOMAS, KLEIN HARALD
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A viral vector comprising: a capsid and a packaged nucleic acid wherein the nucleic acid enhances miRNA down-regulated in a bleomycin-induced pulmonary fibrosis model or in an AAV-TGF [beta] 1-induced pulmonary fibrosis model, or wherein the nucleic acid inhibits miRNA up-regulated in a bleomycin-induced pulmonary fibrosis model or in an AAV-TGF [beta] 1-induced pulmonary fibrosis model. 病毒载体，其包含：衣壳和包装的核酸，其中所述核酸增强在博来霉素诱导的肺纤维化模型或在AAV-TGFβ1-诱导的肺纤维化模型中下调的miRNA，或者其中所述核酸抑制在博来霉素诱导的肺纤维化模型或在AAV-TGFβ1-诱导的肺纤维化模型中上调的miRNA。