Pyrazolopyridine derivatives and uses thereof

The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing the expression levels of wide-spaced zinc finger motif (WIZ), or inducing the expression of fetal hemoglobin (HbF), and in the treatment of hereditary hematological diseases (e.g., hemoglobinopathy, e.g., beta-hemoglobinopathy), e.g., sickle cell disease and beta-thalassemia. 本披露内容涉及具有式(I)的化合物和药物组合物以及它们在降低宽间隔的锌指基序(WIZ)表达水平、或诱导胎儿血红蛋白(HbF)表达、以及在治疗遗传性血液病(例如血红蛋白病，例如β-血红蛋白病)，例如镰状细胞病和β-地中海贫血中的用途。