Use and method of heterocyclic compounds for treating diseases associated with kinase resistance mutation

The present invention relates to the use of a heterocyclic compound of formula I for the preparation of a medicament for the treatment or adjunctive treatment of a disease or condition associated with a RET drug resistance mutation in an individual, and to a method of treatment using said heterocyclic compound. #imgabs0#本发明涉及式I的杂环化合物在制备用于治疗或辅助治疗个体中的与RET(Rearranged during transfection)耐药突变相关的疾病或病况的药物中的用途和使用所述杂环化合物的治疗方法。