Construction method and application of oxidized mouse model sensitive to metabolic diseases

The invention discloses a construction method and application of an oxidized mouse model sensitive to metabolic diseases, and belongs to the technical field of animal model construction. The oxidized mouse model sensitive to metabolic diseases is a mouse with a C57BL6 genetic background generated by MsrA gene mutation, a CRISPR/Cas9 gene knockout technology is utilized to successfully construct an MsrA gene knockout (MsrA-/-) mouse, and experimental research finds that under the background condition of high-fat feeding or hereditary hyperlipidemia, the MsrA gene knockout (MsrA-/-) mouse has the advantages that the MsrA gene knockout (MsrA-/-) mouse can be used for preparing the metabolic disease-sensitive oxidized mouse model sensitive to metabolic diseases; the MsrA-/-mouse promotes the sensitivity of occurrence and development of metabolic diseases such as NAFLD, AS, obesity and the like. The MsrA-/-oxidized mouse model constructed by the invention can be used for discussing action mechanisms and molecular