Preparation method of amido-containing aromatic ring dihydropyran-4-ketone compound

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of an amido-containing aromatic ring dihydropyran-4-ketone compound, which comprises the following steps: reacting a raw material solution containing a 2-(allyloxy)-aromatic aldehyde derivative...

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Hauptverfasser: XU XIANGQIN, XIE LONGYONG, PENG SHA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of an amido-containing aromatic ring dihydropyran-4-ketone compound, which comprises the following steps: reacting a raw material solution containing a 2-(allyloxy)-aromatic aldehyde derivative as shown in a formula 1, N-substituted oxamic acid as shown in a formula 2, ammonium persulfate and DMSO (dimethylsulfoxide) in an oxygen-free atmosphere at the temperature of 40-100 DEG C to obtain the amido-containing aromatic ring dihydropyran-4-ketone compound. The amido-containing aromatic ring dihydropyran-4-ketone product as shown in a formula 3 is prepared. The 2-(allyloxy)-aromatic aldehyde derivative raw material reacts with N-substituted oxamic acid by adopting a metal-free catalysis means, and the target product can be obtained only by simply adding ammonium persulfate, so that the problems of complicated synthesis steps, poor substrate applicability, poor yield, unenvironment-friendly method and the li