MRNA multivalent influenza vaccine and preparation method thereof

The invention provides an mRNA multivalent influenza vaccine and a preparation method thereof. The vaccine comprises an mRNA of a recombinant protein H1N1, an mRNA of a recombinant protein H3N2, an mRNA of a recombinant protein H5N1, an mRNA of a recombinant protein H6N1, an mRNA of a recombinant pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	XU MIAO, ZHANG CHUANPENG, QIANG BANGMING, WANG LIXIN, FENG JIANHAI, LIU MINGLU, HAN QINGMEI, JIN HAIFENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention provides an mRNA multivalent influenza vaccine and a preparation method thereof. The vaccine comprises an mRNA of a recombinant protein H1N1, an mRNA of a recombinant protein H3N2, an mRNA of a recombinant protein H5N1, an mRNA of a recombinant protein H6N1, an mRNA of a recombinant protein H7N9, an mRNA of a recombinant protein H9N2, an mRNA of a recombinant protein H11N2, an mRNA of a recombinant protein B-Victoria and an mRNA of a recombinant protein B-Yamagata. The mass concentration of each mRNA in the vaccine is 100 [mu] g/mL; according to the invention, the antigen sequence is optimized, the prepared mRNA multivalent influenza vaccine can stimulate an organism to generate relatively strong immunogenicity, and compared with the mRNA multivalent influenza vaccine prepared before sequence optimization, the antibody titer is obviously improved, the survival rate of a mouse after a challenge test is obviously improved, and the lung virus titer of the mouse is obviously reduced. 本发明提供一种mRNA多价流感