Application of notopterol in preparation of medicine for treating ulcerative colitis

The invention discloses application of notopterol in preparation of a medicine for treating ulcerative colitis. Experiments prove that notopterygium alcohol can significantly improve mouse colitis induced by dextran sodium sulfate, and the notopterygium alcohol is represented by significantly reduci...

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Bibliographische Detailangaben
Hauptverfasser: MAO XIAOJIAN, LU XIAOHUA, YAN YIYUE, ZHENG YONGREN, LI GUOCHEN, WANG TING, LIU JING, KONG WEIJIAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application of notopterol in preparation of a medicine for treating ulcerative colitis. Experiments prove that notopterygium alcohol can significantly improve mouse colitis induced by dextran sodium sulfate, and the notopterygium alcohol is represented by significantly reducing mouse disease activity indexes and significantly improving mouse colon length shortening caused by modeling; the content of MPO in serum is obviously reduced; pathological changes of colon tissues of mice are remarkably relieved, including inflammatory cell infiltration reduction and tissue structure and intestinal gland number recovery; the content of a proinflammatory factor IL-1beta in a colon tissue is remarkably reduced, the inflammatory response of a colon part is relieved, and the compound has remarkable activity of resisting ulcerative colitis and has a good application prospect in preparation of medicines for treating ulcerative colitis. 本发明公开了羌活醇在制备治疗溃疡性结肠炎药物中的用途。经实验证明,羌活醇能显著改善葡聚糖硫酸钠诱导的小鼠结肠炎症,表现为显著降低小鼠