Amide aldehyde dehydrogenase agonist as well as synthesis method and application thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to an amide aldehyde dehydrogenase agonist as well as a synthesis method and application thereof. The amide compounds provided by the invention show relatively high agonistic activity to ALDH2, so that the compounds have the potential of preparing medicines for treating diseases related to ALDH2 activity; and (2) compared with a positive control, the amide compound provided by the invention has the advantages that the activity and the water solubility are obviously improved, and the druggability is better. Therefore, the compound provided by the invention has a good development prospect. 本发明属于药物化学技术领域，具体涉及一类酰胺类醛脱氢酶激动剂、其合成方法及用途。本发明提供的酰胺类化合物显示了对ALDH2较高的激动活性，因此这些化合物具有制备与ALDH2活性相关的疾病的治疗药物的潜力；(2)本发明的酰胺类化合物较阳性对照物活性和水溶性明显提高，有更好的成药性。因此，本发明的化合物具有良好的开发前景。