Application of sodium chromonate as adjuvant in treatment of pancreatic cancer

The invention discloses application of sodium chromonate as an adjuvant in treatment of pancreatic cancer, and belongs to the technical field of biological medicine. Sodium chromate is used as an adjuvant to target tumor infiltrating mast cells to sensitize pancreatic cancer patients, gemcitabine ch...

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Hauptverfasser: PU NING, YIN HANLIN, XIE YUQI, LIU LIANG, WU WENCHUAN, LOU WENHUI, HE TAOCHEN, CHEN QIANGDA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses application of sodium chromonate as an adjuvant in treatment of pancreatic cancer, and belongs to the technical field of biological medicine. Sodium chromate is used as an adjuvant to target tumor infiltrating mast cells to sensitize pancreatic cancer patients, gemcitabine chemotherapy and anti-PD-1 immunotherapy are used, sodium chromate is used as a mast cell stabilizer, and the sensitivity of pancreatic cancer to gemcitabine chemotherapy and anti-PD-1 immunotherapy can be safely and remarkably improved. According to the present invention, with the application of the sodium chromonate as the pancreatic cancer treatment adjuvant, the tumor volume after the gemcitabine combined anti-PD-1 antibody treatment can be significantly reduced, and the tumor recurrence and metastasis can be reduced so as to prolong the survival of the patient and improve the prognosis of the patient, such that the extremely high practical value is provided in the safety and the economy. 本发明公开了色苷酸钠作为佐剂在治疗胰腺癌中的应用