Anti-PAR-2 antibodies and methods of use thereof

The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PAR-2 and compositions comprising such antibodies or antigen-binding fragments thereof. In particular aspects, the antibody, or antigen-binding fragment thereof, that specifically binds t...

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Bibliographische Detailangaben
Hauptverfasser:	BRACKEN ANNA MICHAELA, SAVATIEL MARTA, LIDARMANT, MARK, TERENCE, ROSENFELD JULIA, POULTON LYNN, DOYLE ANTHONY GERARD, COOKSEY, BRIGITTE, A, QUIGLEY ANA MARIA MATILDA, CLARK ADAM, POLLARD, MATTHEW
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to human PAR-2 and compositions comprising such antibodies or antigen-binding fragments thereof. In particular aspects, the antibody, or antigen-binding fragment thereof, that specifically binds to human PAR-2 blocks the interaction between a PAR-2 activating ligand and the extracellular domain of PAR-2, and/or blocks the activation of PAR-2 by a PAR-2 activating ligand. In further aspects, the antibodies or antigen-binding fragments may be used to treat diseases or disorders associated with increased PAR-2 expression and/or diseases or disorders that may be ameliorated by antagonizing PAR-2 activation of PAR-2 activating ligands (e.g., airway diseases, skin diseases, cancer, oral granulomatosis, inflammatory disorders, and pain associated with various diseases or disorders). 本公开提供了特异性结合人PAR-2的抗体及其抗原结合片段和包含此类抗体或其抗原结合片段的组合物。在具体的方面，特异性结合人PAR-2的所述抗体或其抗原结合片段阻断PAR-2激活配体与PAR-2的细胞外结构域之间的相互作用，和/或阻断PAR-2激活配体激活PAR-2。