Nano antibody for resisting guanylate cyclase 2C and application of nano antibody

The invention discloses a nano antibody for resisting guanylate cyclase 2C and application of the nano antibody. The amino acid sequence of the CDR1 of the nano antibody comprises a sequence as shown in SEQ ID NO.1, SEQ ID NO.2 or SEQ ID NO.3, the amino acid sequence of the CDR2 of the nano antibody...

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Bibliographische Detailangaben
Hauptverfasser:	YU XUEJUN, CHEN XIN, DI SHENGMENG, ZHOU XI, LI ZHAORUN, MA HENG, FENG DONGGE, ZHAO ZUOSHUN, FAN YANQIU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a nano antibody for resisting guanylate cyclase 2C and application of the nano antibody. The amino acid sequence of the CDR1 of the nano antibody comprises a sequence as shown in SEQ ID NO.1, SEQ ID NO.2 or SEQ ID NO.3, the amino acid sequence of the CDR2 of the nano antibody comprises a sequence as shown in SEQ ID NO.4, SEQ ID NO.5, SEQ ID NO.6, SEQ ID NO.7, SEQ ID NO.8, SEQ ID NO.9 or SEQ ID NO.10, and the amino acid sequence of the CDR3 of the nano antibody comprises a sequence as shown in SEQ ID NO.11, SEQ ID NO.12 or SEQ ID NO.13. The invention further discloses a preparation method of the nano antibody. The nano antibody for resisting guanylate cyclase 2C can be specifically combined with a guanylate cyclase 2C antigen, is good in affinity, and has obvious killing activity on guanylate cyclase 2C positive tumor cells when being used as an antigen binding structural domain to construct a chimeric antigen receptor and a CAR-T (Chimeric Antigen Receptor-T) cell. 本发明公开了一种抗鸟苷酸环化酶2C的纳米