Method for improving yield of cordycepin produced by liquid fermentation of cordyceps militaris through graded components of silkworm chrysalis

A method for increasing the yield of cordycepin produced by cordyceps militaris liquid fermentation through silkworm chrysalis graded components comprises the steps that the silkworm chrysalis graded components are prepared according to polarity and solubility, silkworm chrysalis aqueous extract graded components are added in the cordyceps militaris liquid fermentation process, and a multiple fermentation system of sucrose and silkworm chrysalis globulin liquid fermentation feeding-pH control is constructed. The continuous fermentation cannot be realized, and the supplemented raw materials are expensive, and the yield of cordycepin is obviously improved. And theoretical basis and application significance are provided for industrial continuous production of cordycepin. 一种蚕蛹分级组分提高蛹虫草液体发酵产虫草素产量的方法，根据极性和溶解性制备蚕蛹分级组分，在蛹虫草液体发酵过程中添加蚕蛹水提物分级组分，构建蔗糖、蚕蛹球蛋白液体发酵补料-控制pH的多重发酵体系，克服了发酵工艺产量低，无法连续发酵，补料原料昂贵等问题，显著提高虫草素产量。对于虫草素工业化连续化生产提供理论依据和应用意义。