Hydrogel preparation method and application of sorbitol-dopamine-compound multifunctional material

The invention discloses a preparation method and application of a hydrogel of a sorbitol-dopamine-compound multifunctional material. Firstly, sorbitol and acrylic anhydride are subjected to an esterification reaction to obtain corresponding ester, and then through a Michael addition reaction, the obtained ester, dopamine hydrochloride and polyethylene glycol diacrylate are synthesized into the acrylate-terminated hyperbranched polymer under the condition that the ratio of double bonds to active hydrogen is 1.8: 1. The composite hydrogel is prepared by taking sorbitol and dopamine as raw materials, the hydrogel is easy to degrade and has better adhesiveness and biocompatibility, and the raw materials are numerous in acquisition way, simple in process and easy to prepare. 本发明公开一种山梨醇-多巴胺-复合物多功能材料的水凝胶制备方法及其应用。首先将山梨醇和丙烯酸酐通过酯化反应得到相应的酯，然后通过迈克尔加成反应，以双键与活性氢的比例为1.8:1的条件，将得到的酯与盐酸多巴胺、聚乙二醇二丙烯酸酯合成丙烯酸酯端基超支化聚合物。本发明以山梨醇和多巴胺为原料制备的一种复合型水凝胶，该水凝胶易于降解，拥有较好的粘合性和生物相容性，且原料获取途径众多，过程简单，易于制备。