Application of ZNF92 gene in preparation of anti-glioblastoma drug

The invention belongs to the field of treatment of glioblastoma, and particularly relates to application of a ZNF92 gene in preparation of anti-glioblastoma drugs. According to the invention, a new treatment strategy for inhibiting brain glioma epithelial-mesenchymal transition by targeting ZNF92 is explored, an intracranial in-situ animal model is constructed, and the biological process that ZNF92 transcriptionally activates HSPA5 escape ferroptosis and further regulates and controls the brain glioma epithelial-mesenchymal transition is verified. The important regulation and control effect of a ZNF92 mediated ferroptosis event in the brain glioma epithelial-mesenchymal transition process is clarified, a new mechanism of malignant development of the brain glioma is found, potential treatment targets are excavated, and a GBM effective treatment strategy is explored. 本发明属于胶质母细胞瘤治疗领域，具体涉及ZNF92基因在制备抗胶质母细胞瘤药物中的应用。本发明探索靶向ZNF92抑制脑胶质瘤上皮间质转化的治疗新策略，构建了颅内原位动物模型，验证ZNF92转录激活HSPA5逃逸铁死亡进而调控脑胶质瘤上皮间质转化的生物学过程。本发明阐明ZNF92介导铁死亡事件