Targeted lipid nanocapsule loaded with daphnetin as well as preparation method and application of targeted lipid nanocapsule

The invention provides a target lipid nanocapsule loaded with daphnetin as well as a preparation method and application of the target lipid nanocapsule, and relates to the technical field of biological medicines. The targeting lipid nanocapsule prepared by the invention has stability and biological safety, and the targeting property of the targeting lipid nanocapsule is verified in vivo and in vitro. Meanwhile, compared with pure daphnetin treatment, the targeted lipid nanocapsule disclosed by the invention is verified to be more obvious in treatment effect from macroscopic and microscopic angles. Daphnetin can be better enriched around the injured spinal cord through the targeting lipid nanocapsule, so that the bioavailability of the medicine is improved. The daphnetin-loaded targeted lipid nanocapsule provided by the invention can provide a new scheme for treatment of spinal cord injury. 本发明提供了一种负载瑞香素的靶向脂质纳米囊及其制备方法和应用，涉及生物医药技术领域。本发明制备得到的靶向脂质纳米囊具有稳定性及生物安全性，并且在体内、体外两个方面，验证了所述靶向脂质纳米囊的靶向性。同时，分别从宏观和微观角度验证相对于单纯瑞香