Method for measuring chromatographic purity of 2, 4, 6-trimethylbenzenesulfonyl chloride by utilizing HPLC (High Performance Liquid Chromatography)

The invention relates to the technical field of detection and analysis, in particular to a method for determining chromatographic purity of 2, 4, 6-trimethylbenzenesulfonyl chloride by utilizing HPLC (High Performance Liquid Chromatography), which comprises the following conditions: a stationary phase is an octadecylsilane bonded phase, mobile phases comprise a mobile phase A and a mobile phase B, the mobile phase A is a monopotassium phosphate buffer salt solution, and the mobile phase B is acetonitrile; the method can effectively separate the 2, 4, 6-trimethylbenzenesulfonyl chloride, mesitylene and hydrolysis impurity 2, 4, 6-trimethylbenzene sulfonic acid in the 2, 4, 6-trimethylbenzenesulfonyl chloride product, is high in separation degree and sensitivity, does not generate interference impurities, and can accurately measure the purity of the 2, 4, 6-trimethylbenzenesulfonyl chloride in the product. 本发明涉及检测分析技术领域，尤其是涉及一种利用HPLC测定2,4,6-三甲基苯磺酰氯色谱纯度的方法，该方法包括以下条件：固定相为十八烷基硅烷键合相，流动相包括流动相A和流动相B，所述流动相A为磷酸二氢钾缓冲盐溶液