Synthesis method of Boc-Tyr (tBu)-Aib-OH

The invention discloses a synthesis method of Boc-Tyr (tBu)-Aib-OH, and belongs to the technical field of polypeptide synthesis. The synthesis method of Boc-Tyr (tBu)-Aib-OH provided by the invention comprises the following synthesis steps: (1) enabling Boc-Tyr (tBu)-OH and H-Aib-OR.HCl to react under the condition of a condensation reagent, so as to obtain a Boc-Tyr (tBu)-Aib-OR crude product; (2) crystallizing and purifying the Boc-Tyr (tBu)-Aib-OR crude product to obtain a Boc-Tyr (tBu)-Aib-OR refined product; and (3) hydrolyzing the Boc-Tyr (tBu)-Aib-OR refined product under an alkaline condition to obtain Boc-Tyr (tBu)-Aib-OH. The purity of the product finally obtained through the synthesis method reaches 99.5% or above, the content of unknown single impurities is 0.1% or below, the content of isomer impurities is 0.1% or below, and the total yield is high and reaches 80% or above. The method is simple to operate and very suitable for industrial production. 本发明公开了一种Boc-Tyr(tBu)-Aib-OH的合成方法，属于多肽合成技术领域。本发明