Application of Sigmar1 gene inhibitor in preparation of medicine for treating or preventing type 2 diabetes mellitus

The invention belongs to the technical field of biological medicines, and particularly relates to application of a Sigmar1 gene inhibitor in preparation of a medicine for treating or preventing type 2 diabetes mellitus. The invention finds that the deletion of the Sigmar1 gene can obviously reduce the blood sugar content of rats with high-fat diet induced type 2 diabetes mellitus, and can improve the glucose tolerance and insulin sensitivity of the rats with high-fat diet induced type 2 diabetes mellitus. Therefore, the Sigmar1 gene can be used as a new target for regulating and controlling the type 2 diabetes mellitus, a new way is provided for preventing and treating the type 2 diabetes mellitus induced by high fat diet, and the Sigmar1 gene has an important application prospect in treatment of the type 2 diabetes mellitus. 本发明属于生物医药技术领域，具体涉及Sigmar1基因抑制剂在制备治疗或预防2型糖尿病的药物中的应用。本发明发现Sigmar1基因的缺失能够显著降低高脂饮食诱导的2型糖尿病大鼠的血糖含量，并且能够改善其葡萄糖耐受性和胰岛素敏感性。因此，Sigmar1基因可作为调控2型糖尿病的新的靶点，为高脂饮食诱导的2型糖尿病的防治提供新的途径，对2型糖尿病的治疗具有重要的应用前景。