Completely humanized single-domain tandem chimeric antigen receptor (CAR) targeting CD5 and application thereof

The invention discloses a fully human single-domain tandem chimeric antigen receptor (CAR) capable of being specifically bound with CD5 protein. The fully human single-domain tandem chimeric antigen receptor (CAR) comprises a CD5 binding structural domain, a transmembrane structural domain, a costimulatory structural domain and an intracellular signal transduction structural domain. Also provided are engineered immune effector cells, such as T cells, comprising the chimeric antigen receptors and the use of the CARs and engineered immune effector cells for the treatment of diseases or conditions associated with the expression of CD5. 一种可以特异性结合CD5蛋白的全人源单域串联嵌合抗原受体(CAR)，其包含CD5结合结构域、跨膜结构域、共刺激结构域和胞内信号传导结构域。还提供了包含所述嵌合抗原受体的经工程化的免疫效应细胞(诸如T细胞)以及所述CAR及工程化的免疫效应细胞在用于治疗与CD5的表达相关的疾病或病症中的应用。