Bladder perfusion medicine composition as well as preparation method and application thereof

The invention relates to a bladder perfusion medicine composition which comprises an immunologic adjuvant or soluble salt thereof and a chemical medicine capable of causing death of immunogenic cells. When the immunologic adjuvant and the soluble salt thereof are combined with a chemical drug capable of causing death of immunogenic cells as a bladder perfusion drug for use, the side effect of the chemical drug can be reduced, a synergistic anti-cancer effect can be generated, and the probability of cancer metastasis and relapse can be reduced. The invention also provides a preparation method and application of the bladder perfusion pharmaceutical composition. 本申请涉及一种膀胱灌注药物组合物，其包括免疫佐剂或其可溶性盐，以及能引起免疫原性细胞死亡的化药。所述免疫佐剂及其可溶性盐与能引起免疫原性细胞死亡的化药做为膀胱灌注药物联用时，能够在减少化药副作用的同时，产生协同抗癌作用，降低癌症转移及复发的概率。本申请还提供了所述膀胱灌注药物组合物的制备方法及其用途。