Self-sustained-release immunologic adjuvant suspension as well as preparation method and application thereof

The invention discloses a self-sustained-release immunologic adjuvant suspension, which is characterized in that a fat-soluble immunologic adjuvant and a surfactant form micron-sized particles, the balance is a dispersant, the fat-soluble immunologic adjuvant is coated with the surfactant to form th...

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Bibliographische Detailangaben
Hauptverfasser: TAO HUIQUAN, DENG ZHONGQING, KASHIWAGAMI, ZHOU XUANFANG, LIU ZHUANG, WU YUCHEN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a self-sustained-release immunologic adjuvant suspension, which is characterized in that a fat-soluble immunologic adjuvant and a surfactant form micron-sized particles, the balance is a dispersant, the fat-soluble immunologic adjuvant is coated with the surfactant to form the micron-sized particles, and the micron-sized particles are dispersed in the dispersant to form the suspension. The self-sustained-release immunologic adjuvant suspension can be detained in tumors for a long time and maintain the sustained-release performance, and also can inhibit the growth of distal metastatic tumors and reduce the probability of tumor recurrence through immunoreaction. The invention also provides a preparation method of the self-sustained-release immunologic adjuvant suspension and application of the self-sustained-release immunologic adjuvant suspension in a sensitizing preparation for tumor treatment such as radiotherapy, chemotherapy or thermal therapy. 本发明公开了一种自缓释免疫佐剂混悬液,由脂溶性免疫佐剂和表面活性剂组成微米颗