Lactobacillus plantarum capable of producing indole derivative through metabolism of L-tryptophan and having function of enhancing intestinal barrier and application of lactobacillus plantarum

The invention discloses lactobacillus plantarum capable of producing an indole derivative by metabolizing L-tryptophan and having a function of enhancing intestinal barrier as well as a screening method and application of the lactobacillus plantarum, and belongs to the technical field of microorgani...

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Hauptverfasser:	WANG TIEQI, TUO YANFENG, SONG YINGLONG, WANG ARONG, MOU GUANGQING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses lactobacillus plantarum capable of producing an indole derivative by metabolizing L-tryptophan and having a function of enhancing intestinal barrier as well as a screening method and application of the lactobacillus plantarum, and belongs to the technical field of microorganisms. The lactobacillus plantarum DPUL-S164 disclosed by the invention can be used for metabolizing L-tryptophan in vivo and in vitro to generate ILA and IAId; the application has the advantages that DSS-induced Balb/c mouse weight loss, disease activity index increase and colon length shortening can be relieved, the level of anti-inflammatory cytokine IL-10 is increased by lowering the level of serum proinflammatory factors IL-6 and TNF-alpha, the increase of mucoprotein and tight junction protein is promoted by activating an AhR signal channel, the damaged intestinal barrier is improved, and the application prospect is good. 本发明公开了一种代谢L-色氨酸产吲哚衍生物且具有增强肠道屏障功能的植物乳杆菌及其筛选方法与应用，属于微生物技术领域。本发明的植物乳杆菌DPUL-S164可以在体内外代谢L-色氨酸产