African swine fever virus antigen epitope peptide, monoclonal antibody and application thereof

The invention belongs to the technical field of biological medicine. Specifically, the invention discloses an African swine fever virus antigen epitope peptide or a coding nucleic acid thereof, a monoclonal antibody specifically bound with an African swine fever virus S273R protein antigen epitope,...

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Bibliographische Detailangaben
Hauptverfasser:	ZHAO YANYAN, LIU SHUNDA, LING XIANGHUI, REN HAOJIE, ZHANG GAIPING, YANG ZHAOYUAN, ZHANG YUHANG, GUO KEWEI, LIN ZHIZHAO, WAN BO, SHI SAIYAN, ZHANG BIAO, HAN SEUNG, HE WENRUI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention belongs to the technical field of biological medicine. Specifically, the invention discloses an African swine fever virus antigen epitope peptide or a coding nucleic acid thereof, a monoclonal antibody specifically bound with an African swine fever virus S273R protein antigen epitope, a hybridoma cell strain secreting the monoclonal antibody and application of the hybridoma cell strain in preparation of drugs for preventing and/or treating African swine fever virus infection. The invention also relates to application in a reagent for detecting and/or diagnosing African swine fever virus infection. The antigenic epitope of the African swine fever virus S273R protein provided by the invention is a B cell linear epitope, the minimum antigenic epitope is located at the 136th-140th amino acid of the S273R protein, and the antigenic epitope is a truncated peptide containing an EELQY core sequence (as shown in SEQ ID NO: 3). The monoclonal antibody provided by the invention can specifically recognize a