Compound containing five-membered heteroaromatic ring structure as well as pharmaceutical composition and application thereof

The invention discloses a compound containing a five-membered heteroaromatic ring structure as well as a pharmaceutical composition and application thereof. The invention provides a compound containing a five-membered heteroaromatic ring structure as shown in a formula I, and pharmaceutically acceptable salts, stereoisomers, tautomers or isotope compounds thereof. The compound containing the five-membered heteroaromatic ring structure is expected to be used for treating and/or preventing various diseases related to poly adenosine diphosphate ribose hydrolase (PARG). 本发明公开了一种含五元杂芳环结构化合物、其药物组合物及应用。本发明提供了一种如式I所示的含五元杂芳环结构化合物、其药学上可接受的盐、其立体异构体、其互变异构体或其同位素化合物。该含五元杂芳环结构化合物有望用于治疗和/或预防与聚腺苷二磷酸核糖水解酶(PARG)相关的多种疾病。