Preparation method of gabapentin with controllable particle size

The invention discloses a preparation method of gabapentin with controllable particle size, which comprises the following steps: (1) adding gabapentin hydrochloride into water, regulating the pH value of the system, and preserving heat for crystallization; centrifuging and leaching to obtain a gabapentin hydrate crude product; controlling the chloride ion concentration in the gabapentin hydrate crude product by leaching; (2) adding the gabapentin hydrate crude product into ethanol, adding an additive, heating, preserving heat for crystal transformation, and centrifuging to obtain a gabapentin refined product; and the additive is acetate. By controlling the content of chloride ions in the gabapentin hydrate and adding the additive during crystal transformation, the obtained gabapentin is uniform in particle size distribution, and products meeting different particle size and bulk density requirements can be obtained through a simple size stabilization mode or sieving. 本发明公开了一种粒径可控的加巴喷丁制备方法，包括以下步骤：(1)将加巴喷丁盐酸盐加入水