Application of USP21-MOF regulation axis in preparation of drugs for targeted therapy of esophageal squamous cell carcinoma

The invention relates to application of a USP21-MOF regulation axis in preparation of drugs for targeted therapy of esophageal squamous cell carcinoma. And the USP21-MOF regulation and control axis comprises a USP21 gene and an MOF gene. The mRNA nucleotide sequence of the USP21 gene is as shown in...

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Bibliographische Detailangaben
Hauptverfasser:	LI PEICHAO, LI PENG, ZHAO YUNPENG, ZOU YONGXIN, LI LINGBING, GUO JIAZHONG, SUI HUACONG, ZHAO XIAOGANG, YANG LINGXIAO, TIAN ZHONGXIAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to application of a USP21-MOF regulation axis in preparation of drugs for targeted therapy of esophageal squamous cell carcinoma. And the USP21-MOF regulation and control axis comprises a USP21 gene and an MOF gene. The mRNA nucleotide sequence of the USP21 gene is as shown in SEQ ID NO. 1, and the mRNA nucleotide sequence of the MOF gene is as shown in SEQ ID NO. 2. According to the invention, it is found for the first time that proliferation, migration and invasion of esophageal squamous cell carcinoma cells can be effectively inhibited through interference inhibition of a USP21-MOF regulatory axis, and si-USP21, si-MOF and si-UM which specifically knock down expression levels of mRNA of USP21 and MOF are designed. The invention also finds that the inhibition effect of knocking down the mRNA expression level of USP21 and MOF at the same time on a USP21-MOF regulation axis is optimal, the effect of inhibiting proliferation and metastasis of esophageal squamous cell carcinoma is optimal,