Triethylenetetramine tetrahydrochloride as well as preparation method and composition thereof

The invention provides a preparation method of triethylenetetramine tetrahydrochloride crystals, which comprises the following steps: adding an anti-solvent into a triethylenetetramine tetrahydrochloride aqueous solution at a feeding temperature, and stirring to separate out the crystals; wherein the feeding temperature is 50 DEG C to 75 DEG C; the anti-solvent is an alcohol solvent. The invention also provides a novel triethylenetetramine tetrahydrochloride, the crystal of the triethylenetetramine tetrahydrochloride has an XRPD pattern with peak values at 21.9, 24.8, 25.2, 28.0 and 35.6 +/-0.1 degree 2 theta, and the composition prepared by using the triethylenetetramine tetrahydrochloride has the advantage of stable storage. 本发明提供一种三亚乙基四胺四氢氯化物晶体的制备方法，其是包含将一反溶剂在一进料温度下添加至一三亚乙基四胺四氢氯化物水溶液中，并搅拌析出晶体；其中，该进料温度为50℃～75℃；该反溶剂为醇类溶剂。本发明也提供一种新颖的三亚乙基四胺四氢氯化物，其晶体是具有在21.9、24.8、25.2、28.0及35.6±0.1°2θ处具有峰值的XRPD图案，使用本发明的三亚乙基四胺四氢氯化物所制成的组合物具有可稳定存放的优势。